Author:
Nakanishi Takahisa,Nakaya Aya,Nishio Yusuke,Fujita Shinya,Satake Atsushi,Azuma Yoshiko,Tsubokura Yukie,Saito Ryo,Konishi Akiko,Hotta Masaaki,Yoshimura Hideaki,Kadosaka Yoshihiko,Ishii Kazuyoshi,Ito Tomoki,Tsuta Koji,Nomura Shosaku
Abstract
A 63-year-old man was diagnosed with a rare variant of acute promyelocytic leukemia (APL) with t(4;17)(q12; q21) that showed atypical morphological features and two different clinical symptoms. He was started on standard induction chemotherapy for acute myeloid leukemia, which decreased myeloblast numbers; however, APL-like blasts remained. He then received a salvage therapy that added all-trans retinoic acid (ATRA). After ATRA commenced, APL-like blasts disappeared and cytogenetic analysis became normal. However, myeloblasts subsequently increased, and he became resistant. In summary, this patient exhibited two different clinical courses of acute myeloid leukemia and APL.
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