ROLE OF PULLING DIRECTION IN UNDERSTANDING THE ANISOTROPY OF THE RESISTANCE OF PROTEINS TO FORCE-INDUCED MECHANICAL UNFOLDING-Reference-Cited by-同舟云学术

ROLE OF PULLING DIRECTION IN UNDERSTANDING THE ANISOTROPY OF THE RESISTANCE OF PROTEINS TO FORCE-INDUCED MECHANICAL UNFOLDING

Published:2010-02-20 Issue:04n05 Volume:24 Page:379-399
ISSN:0217-9849
Container-title:Modern Physics Letters B
language:en
Short-container-title:Mod. Phys. Lett. B

Author:

JENSEN I.¹,GIRI D.²,KUMAR S.³

Affiliation:

1. Department of Mathematics and Statistics, The University of Melbourne, Victoria 3010, Australia

2. Department of Applied Physics, Institute of Technology, Banaras Hindu University, Varanasi 221 005, India

3. Department of Physics, Banaras Hindu University, Varanasi 221 005, India

Abstract

Recent advances in single molecule experiments have made it possible to investigate the mechanical anisotropy of protein stability in greater detail. It has been found that proteins can exhibit a diverse range of responses when pulled in different directions. We review some of the experimental and numerical work related to the study of the resistance of proteins to force-induced mechanical unfolding. Based on model studies in the framework of statistical mechanics, we discuss the possible molecular origin of the anisotropy of protein resistance to unfolding.

Publisher

World Scientific Pub Co Pte Lt

Subject

Condensed Matter Physics,Statistical and Nonlinear Physics

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0217984910022469

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