Stability and Stochastic Resonance for a Time-Delayed Cancer Development System Subjected to Noises and Multiplicative Periodic Signal

Abstract

In this paper, the stability and the phenomenon of stochastic resonance (SR) for a stochastic time-delayed cancer development system that is induced by the multiplicative periodic signal, the multiplicative and the additive noises are investigated. By using the fast descent method, small time delay method and the two-state theory, the expressions of the steady state probability distribution function and the signal-to-noise ratio (SNR) are obtained. Numerical results reflect that the multiplicative and additive noise always restrain the diffusion of the cancer cells. Whereas, the time delay can not only control the spread of the tumor cells, but also suppress the extinction of cancer cells. Meanwhile, the conventional SR occurs in the tumor cell growth model under the excitation of different noises and time delay. In conclusion, the multiplicative noise always plays a critical role in restraining SR, a smaller additive noise can stimulate the SR, but the larger additive noise can weaken the SR and SNR. In particular, the time delay displays relatively complicated effects on the SR phenomenon of the system. It plays different roles in motivating or suppressing SR under the different conditions of parameters.