AN ATOMIC BASIS STUDY ON CANCER: - HERB MEDICINE ADDITIVE LANTHANIDE-HPD LOCALIZATION IN ANIMAL TUMOR -

Author:

WEI CHAU-CHIN1,TOMINAGA YASUO2,TSAI JUI-CHANG3,CHAI CHEE-YIN4,WU WU-SIUNG5

Affiliation:

1. Department of Physics, Tsing Hua University Hsinchu, Taiwan

2. Shinmachi Clinic 21–12 Ajiroshinmachi, Higashi-Osaka City, Japan

3. Department of Surgery, Taiwan University Hospital Taipei, Taiwan

4. Department of Pathology, Kaohsiung Medical College Kaohsiung, Taiwan

5. Instrument Division, Nuclear Science and Technology Development Center, Tsing Hua University Hsinchu, Taiwan

Abstract

The particle induced X-ray emission analysis is applied to mark (or to localize) a cancer lesion from its benign environment in animal experiments. As a photosensitiser, we have used hematoporphyrin derivative (HPD) and in order to make HPD visible to PIXE, we synthesize HPD with rare earth metals to form lanthanide-HPD to enhance the localizing efficiency tremendously and PIXE is used as a straightforward detection method to find the successfulness of the synthesis. In theory, this approach can be used to probe carcinogenesis at cell levels. To increase the cure effects of lanthanide-HPD, we add ZYX to enhance the pharmaceutical effectiveness. ZYX, our code name for a group of drugs and chemicals, is mostly of the Chinese herb extraxctions but some has different origin. We explain the present approach with a specific experiment, Dysprosium-HPD (Dy-HPD) as a localizer, and conclude this article with some comments and perspectives.

Publisher

World Scientific Pub Co Pte Lt

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. M-SHELL X-RAY TRANSITION RATES FOR HEAVY RARE EARTH ELEMENTS;International Journal of PIXE;1998-01

2. An atomic basis of cancer (VI) — PIXE comparison of tumor localizers;Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms;1996-04

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