Enhanced radiation effect on tumor growth using oxygen-rich microcapsules-Reference-Cited by-同舟云学术

Enhanced radiation effect on tumor growth using oxygen-rich microcapsules

Published:2013-01 Issue:01n02 Volume:23 Page:39-45
ISSN:0129-0835
Container-title:International Journal of PIXE
language:en
Short-container-title:Int. J. PIXE

Author:

Harada S.¹,Ehara S.¹,Ishii K.²,Sato T.³,Koka M.³,Sera K.⁴,Goto S.⁴

Affiliation:

1. Iwate Medical University Department of Radiology, Morioka, Japan

2. Department of the Quantum Science and Energy Engineering, Tohoku University, Sendai, Japan

3. Takasaki Institute of the Radiation Chemistry Research Establishment, JAERI, Takasaki, Japan

4. Cyclotron Center of Iwate Medical University, Takizawa, Tomegamori, Japan

Abstract

The aim of this study was to determine whether oxygen-releasing microcapsules could be used to sensitize cancer cells to kill by radiation. The microcapsules were generated by spraying a mixture of 0.1% alginate and hyaluronic acid into a 0.3 mmol/l solution of CaCl2 and FeCl2. These were then subcutaneously injected around a MM48 tumor (a cell line derived from human breast cancer) in the left hind legs of C3H/HeN mice, and tumors were dosed with 60Co γ-ray radiation. We showed that the oxygen released from the microcapsules enhanced the anti-tumor effect of radiation treatment via the generation of oxygen radicals.

Publisher

World Scientific Pub Co Pte Lt

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0129083513400056

Reference4 articles.

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2. IMPROVED RADIOSENSITIVE MICROCAPSULES USING H2O2

3. Ascorbic Acid Oxidation by Hydrogen Peroxide

4. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy