RESEARCH OF DISEASE ONSET MECHANISM BY DETERMINING THE DISTRIBUTION OF INTRACELLULAR TRACE ELEMENTS USING AN IN-AIR MICRO-PIXE ANALYZER SYSTEM-Reference-Cited by-同舟云学术

RESEARCH OF DISEASE ONSET MECHANISM BY DETERMINING THE DISTRIBUTION OF INTRACELLULAR TRACE ELEMENTS USING AN IN-AIR MICRO-PIXE ANALYZER SYSTEM

Published:2006-01 Issue:01n02 Volume:16 Page:69-76
ISSN:0129-0835
Container-title:International Journal of PIXE
language:en
Short-container-title:Int. J. PIXE

Author:

NAKANO TAKASHI¹,ARAKAWA KAZUO²,SAKURAI HIDEYUKI¹,HASEGAWA MASATOSHI¹,YUASA KAZUHISA¹,SAITO ETSUKO¹,TAKAGI HITOSHI¹,NAGAMINE TAKEAKI³,KUSAKABE TAKAHIKO³,TAKADA HISASHI³,NAKAZATO KYOUMI³,SUZUKI KEIJI³,KAMIYA TOMIHIRO²,SATOH TAKAHIRO²,OIKAWA MASAKAZU²,SAKAI TAKURO²

Affiliation:

1. Graduate School of Medicine, Gunma University, Maebashi, Gunma 3718511, Japan

2. Takasaki Advanced Radiation Research Institute, Japan Atomic Energy Agency (JAEA), Takasaki, Gunma 3701292, Japan

3. School of Health, Gunma University, Maebashi, Gunma 3718511, Japan

Abstract

A program was started to create a new medical scientific field, which involves radiation oncology and nuclear medicine, utilizing advanced accelerator and ion beam technology. An in-air micro-PIXE analyzer system, which is among the most important technical aspects of the program, was upgraded to improve the accuracy of elemental mapping for samples with thickness variation in the scope of microbeam scanning. In order to address important bio-medical problems in cancer, the intracellular dynamics of trace elements according to the development mechanism of diseases were studied using this system. This paper outlines the program, showing correction of micro-PIXE elemental map by STIM analysis and the preliminary application results.

Publisher

World Scientific Pub Co Pte Lt

Link

https://www.worldscientific.com/doi/pdf/10.1142/S0129083506000824

Reference14 articles.

1. APPLICATION OF MICRO-PIXE CAMERA TO ELEMENTAL ANALYSIS OF A SINGLE CELL

2. Sub-micron microbeam apparatus for high resolution materials analyses

3. Investigation of the uptake of drugs, carcinogens and mutagens by individual mammalian cells using a scanning proton microprobe

4. A survey of recent PIXE applications in archaeometry and environmental sciences using the Oxford scanning proton microprobe facility

5. PIXE microanalysis in human cells: physiology and pharmacology

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