Design, Synthesis and Evaluation of Pyrrol-thiazole Derivatives as AChE and BuChE Inhibitory and Antioxidant Activities-Reference-Cited by-同舟云学术

Design, Synthesis and Evaluation of Pyrrol-thiazole Derivatives as AChE and BuChE Inhibitory and Antioxidant Activities

Published:2023-12-28 Issue:4 Volume:44 Page:625-628
ISSN:2587-2680
Container-title:Cumhuriyet Science Journal
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Author:

ACAR ÇEVİK Ulviye¹^ORCID,ERCETİN Tugba²^ORCID

Affiliation:

1. ANADOLU ÜNİVERSİTESİ

2. EASTERN MEDITARRANEAN UNIVERSITY

Abstract

Thiazole rings are one of the most frequently used heterocyclic moieties and are found in a wide variety of biologically active chemicals. In this research project, we report the synthesis and biological activities of some new thiazole derivatives (2a-2c) as potent anti-Alzheimer’s agents. These final compounds’ structures were characterized by spectral (1H NMR, 13C NMR, and MS spectra) analyses. The highest inhibitory activity against AChE was demonstrated by compound 2c (23.73 ± 0.018 %) with chloro substitution at the meta and para positions of the phenyl ring, while the highest inhibitory activity against BuChE was produced by compound 2a (28.87± 0.003 %) with cyano substitution at the f position of the phenyl ring. Ferrous ion-chelating and DPPH techniques were also used to assess the compounds' antioxidant properties. Compound 2a showed antioxidant effect according to the DPPH method with an IC50 value of 27.18 ± 0.009 µM.

Publisher

Cumhuriyet University

Subject

General Medicine

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