An updated molecular diagnostic for surveillance oftetMinNeisseria gonorrhoeae

Abstract

AbstractDoxycycline post-exposure prophylaxis (doxy-PEP) for sexually transmitted bacterial infections reduces the risk of syphilis and chlamydia, but effectiveness against gonorrhea is variable, likely attributable to varying resistance rates. As doxy-PEP is incorporated into clinical practice, an urgent unanswered question is whether increased doxycycline use will drive tetracycline-class resistance inNeisseria gonorrhoeae. Here, we report an updated RT-PCR molecular diagnostic to detect thetetMgene that confers high-level tetracycline resistance inN. gonorrhoeae.