Epidemiological Analysis of HIV and HPgV Co-infection in a Brazilian Population

Abstract

ABSTRACTObjectivesThis study aimed to determine the prevalence of Human Pegivirus 1 infection among people living with HIV (PLWHIV) in Northeast Brazil and identify associated risk factors, given the potential impact of HPgV on HIV disease progressionMethodsWe conducted a cross-sectional analysis of 249 PLWHIV receiving care at a tertiary hospital in Northeast Brazil. Bivariate and multivariate logistic regression models were used to assess the association between sociodemographic characteristics, risk behaviors, healthcare access, and HPgV infection.ResultsThe prevalence of HPgV infection among the study population was 23.3%. Inhaled drug use emerged as a significant risk factor for HPgV infection in the multivariate analysis.ConclusionsA concerning prevalence of HPgV infection exists among PLWHIV in Northeast Brazil. The identification of inhaled drug use as a risk factor suggests potential transmission routes beyond traditional modes. These findings highlight the need for targeted public health interventions and harm reduction strategies to address this significant public health concern.