Abstract
Cancer cells display common traits and enabling-characteristics previously described as the Hallmarks of Cancer. These occur alongside alterations in the regulatory mechanisms controlling gene transcription. Gene co-expression networks (GCNs) identify correlated sets of genes that might share these mechanisms. We have previously reported loss of long-range co-expression for breast, lung, and kidney cancer GCNs. Here, we extend the study to fifteen tissues. Unlike in healthy phenotypes, the highest cancer gene-pair interactions are intra-chromosomal and their strength decays with base-pair distance. Communities in tumor GCNs are strongly associated with cancer related processes along with a wide presence of adaptive immune response. Riboproteins are highly co-expressed in cancer and normal GCNs, suggesting their relevance for cell viability. The loss of long-range co-expression is not observed in other chronic diseases such as Type-2 Diabetes or Alzheimer’s disease. These results suggest that the loss of long-range co-expression is a common trait in cancer.
Publisher
Cold Spring Harbor Laboratory
Reference95 articles.
1. The Hallmarks of Cancer
2. Douglas Hanahan and Robert A Weinberg . Hallmarks of cancer. an organizing principle for cancer medicine. Primer of the molecular biology of cancer. 2nd ed. Philadelphia: Wolters Kluwer, pages 28–57, 2015.
3. Epigenetic mechanisms and the hallmarks of cancer: An intimate affair;American journal of cancer research,2020
4. Lessons from the Cancer Genome
5. Hallmarks of Cancer: The Next Generation
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