Disk-Drive-Like Operations in the Hippocampus

Abstract

AbstractThe rapid computation of re-playable memories within the hippocampus in the form of spike sequences is a near computer-like operation. Information can be encoded once during the initial experience, and replayed numerous times after in a compressed-time representation [1–8]. Theta oscillations, sharp-wave ripples, and attractor dynamics have been posited to collectively play a role in the formation and replay of memories. However, the precise interplay between these dynamical states remains elusive. Here, we show that the memory formation dynamics and operations of the hippocampus are not just computer-like, but map directly onto the dynamics and operations of a disk-drive. We constructed a tripartite spiking neural network model where the hippocampus is explicitly described as a disk drive with a rotating disk, an actuator arm, and a read/write head. In this Neural Disk Drive (NDD) model, hippocampal oscillations map to disk rotations in the rotating disk network while attractor dynamics in the actuator arm network point to “tracks” (spike assemblies) on the disk. The read/write head then writes information onto these tracks, which have temporally-structured spikes. Tracks can be replayed during hippocampal ripples for consolidation. We confirmed the existence of interneuron-ring-sequences, predicted by the rotating disk network, in experimental data. Our results establish the hippocampus as a brain region displaying explicit, computer-like operations. Based on the known interactions between the hippocampus and other brain areas, we anticipate that our results may lead to additional models that revisit the hypothesis that the brain performs explicit, computer-like operations.