Author:
Casto Amanda M.,Roychoudhury Pavitra,Xie Hong,Selke Stacy,Perchetti Garrett A.,Wofford Haley,Huang Meei-Li,Verjans Georges M. G. M.,Gottlieb Geoffrey S.,Wald Anna,Jerome Keith R.,Koelle David M.,Johnston Christine,Greninger Alexander L.
Abstract
AbstractAmong the most ubiquitous of human pathogens, HSV-1 and HSV-2 are distinct viral species that diverged about six million years ago. At least four ancient HSV-1 x HSV-2 interspecies recombination events have affected the HSV-2 genome, with recombinants and non-recombinants at each locus circulating today. Though interspecies recombination has occurred in the past, its importance in HSV evolution remains incompletely defined. Using 255 newly-sequenced and 219 existing HSV genome sequences, we comprehensively assessed interspecies recombination in HSV. The novel recombinants we identify demonstrate that the sizes and locations of interspecies recombination events in HSV-2 are more variable than previously appreciated. One novel recombinant arose in its current host, showing for the first time that interspecies recombination occurs in contemporary HSV populations. We also demonstrate that interspecies recombination affects T-cell recognition of HSV. Our findings indicate that interspecies recombination can significantly influence genetic variation in and host immunologic response to HSV-2.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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