Author:
Arokiaraj Cynthia M.,Kleyman Michael,Chamessian Alexander,Shiers Stephanie,Kang Byungsoo,Kennedy Meaghan M,Chen Yitao,Dum Richard P.,Patterson Ryan,Lewis David A.,Qadri Yawar,Levine Ariel J.,Price Theodore J.,Pfenning Andreas R.,Seal Rebecca P.
Abstract
SummaryThe spinal dorsal horn transforms incoming somatosensory information and transmits it supraspinally to generate modality-specific sensory percepts. The lack of an established framework for the molecular and cellular organization of the dorsal horn across species has greatly hampered delineating precisely how this region processes somatosensory information, including pain. Furthermore, the translation potential of the rodent work is unclear without data from higher order species. To fill these gaps, we performed single nucleus RNA-sequencing of Rhesus macaque dorsal horn and compared the results to a recently reported meta-analysis of mouse. Because dorsal horn laminae serve as a key organizing principle for function, we also determined the laminar location of each identified cell type. The work provides a comprehensive cross-species cellular and molecular database that will be critical for decoding the logic of dorsal horn somatosensory circuits and validating preclinical targets.
Publisher
Cold Spring Harbor Laboratory
Cited by
2 articles.
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