Detailed stratified GWAS analysis for severe COVID-19 in four European populations

Author:

Degenhardt Frauke,Ellinghaus David,Juzenas Simonas,Lerga-Jaso Jon,Wendorff Mareike,Maya-Miles Douglas,Uellendahl-Werth Florian,ElAbd Hesham,Rühlemann Malte C,Arora Jatin,Özer Onur,Lenning Ole Bernt,Myhre Ronny,Vadla May Sissel,Wacker Eike M,Wienbrandt Lars,Ortiz Aaron Blandino,de Salazar Adolfo,Chercoles Adolfo Garrido,Palom Adriana,Ruiz Agustín,Garcia-Fernandez Alba-Estela,Blanco-Grau Albert,Mantovani Alberto,Zanella Alberto,Holten Aleksander Rygh,Mayer Alena,Bandera Alessandra,Cherubini Alessandro,Protti Alessandro,Aghemo Alessio,Gerussi Alessio,Ramirez Alfredo,Braun Alice,Nebel Almut,Barreira Ana,Lleo Ana,Teles Ana,Kildal Anders Benjamin,Biondi Andrea,Caballero-Garralda Andrea,Ganna Andrea,Gori Andrea,Glück Andreas,Lind Andreas,Tanck Anja,Hinney Anke,Nolla Anna Carreras,Fracanzani Anna Ludovica,Peschuck Anna,Cavallero Annalisa,Dyrhol-Riise Anne Ma,Ruello Antonella,Julià Antonio,Muscatello Antonio,Pesenti Antonio,Voza Antonio,Rando-Segura Ariadna,Solier Aurora,Schmidt Axel,Cortes Beatriz,Mateos Beatriz,Nafria-Jimenez Beatriz,Schaefer Benedikt,Jensen Björn,Bellinghausen Carla,Maj Carlo,Ferrando Carlos,de la Horra Carmen,Quereda Carmen,Skurk Carsten,Thibeault Charlotte,Scollo Chiara,Herr Christian,Spinner Christoph D,Gassner Christoph,Lange Christoph,Hu Cinzia,Paccapelo Cinzia,Lehmann Clara,Angelini Claudio,Cappadona Claudio,Azuure Clinton,Bianco Cristiana,Cea Cristina,Sancho Cristina,Lihaug Hoff Dag Arne,Galimberti Daniela,Prati Daniele,Haschka David,Jiménez David,Pestaña David,Toapanta David,Muñiz-Diaz Eduardo,Azzolini Elena,Sandoval Elena,Binatti Eleonora,Scarpini Elio,Helbig Elisa T,Casalone Elisabetta,Urrechaga Eloisa,Paraboschi Elvezia Maria,Pontali Emanuele,Reverter Enric,Calderón Enrique J,Navas Enrique,Solligård Erik,Contro Ernesto,Arana-Arri Eunate,Aziz Fátima,Garcia Federico,Sánchez Félix García,Ceriotti Ferruccio,Martinelli-Boneschi Filippo,Peyvandi Flora,Kurth Florian,Blasi Francesco,Malvestiti Francesco,Medrano Francisco J,Mesonero Francisco,Rodriguez-Frias Francisco,Hanses Frank,Müller Fredrik,Hemmrich-Stanisak Georg,Bellani Giacomo,Grasselli Giacomo,Pezzoli Gianni,Costantino Giorgio,Albano Giovanni,Cardamone Giulia,Bellelli Giuseppe,Citerio Giuseppe,Foti Giuseppe,Lamorte Giuseppe,Matullo Giuseppe,Baselli Guido,Kurihara Hayato,Neb Holger,My Ilaria,Kurth Ingo,Hernández Isabel,Pink Isabell,de Rojas Itziar,Galván-Femenia Iván,Holter Jan Cato,Afset Jan Egil,Heyckendorf Jan,Kässens Jan,Damås Jan Kristian,Rybniker Jan,Altmüller Janine,Ampuero Javier,Martín Javier,Erdmann Jeanette,Banales Jesus M,Badia Joan Ramon,Dopazo Joaquin,Schneider Jochen,Bergan Jonas,Barretina Jordi,Walter Jörn,Quero Jose Hernández,Goikoetxea Josune,Delgado Juan,Guerrero Juan M,Fazaal Julia,Kraft Julia,Schröder Julia,Risnes Kari,Banasik Karina,Müller Karl Erik,Gaede Karoline I,Garcia-Etxebarria Koldo,Tonby Kristian,Heggelund Lars,Izquierdo-Sanchez Laura,Bettini Laura Rachele,Sumoy Lauro,Sander Leif Erik,Lippert Lena J,Terranova Leonardo,Nkambule Lindokuhle,Knopp Lisa,Gustad Lise Tuset,Garbarino Lucia,Santoro Luigi,Téllez Luis,Roade Luisa,Ostadreza Mahnoosh,Intxausti Maider,Kogevinas Manolis,Riveiro-Barciela Mar,Berger Marc M,Schaefer Marco,Niemi Mari EK,Gutiérrez-Stampa María A,Carrabba Maria,Figuera Basso Maria E.,Valsecchi Maria Grazia,Hernandez-Tejero María,Vehreschild Maria JGT,Manunta Maria,Acosta-Herrera Marialbert,D’Angiò Mariella,Baldini Marina,Cazzaniga Marina,Grimsrud Marit M,Cornberg Markus,Nöthen Markus M,Marquié Marta,Castoldi Massimo,Cordioli Mattia,Cecconi Maurizio,D’Amato Mauro,Augustin Max,Tomasi Melissa,Boada Mercè,Dreher Michael,Seilmaier Michael J,Joannidis Michael,Wittig Michael,Mazzocco Michela,Ciccarelli Michele,Rodríguez-Gandía Miguel,Bocciolone Monica,Miozzo Monica,Ayo Natale Imaz,Blay Natalia,Chueca Natalia,Montano Nicola,Braun Nicole,Ludwig Nicole,Marx Nikolaus,Martínez Nilda,Cornely Oliver A,Witzke Oliver,Palmieri Orazio,Faverio Paola,Preatoni Paoletta,Bonfanti Paolo,Omodei Paolo,Tentorio Paolo,Castro Pedro,Rodrigues Pedro M,España Pedro Pablo,Hoffmann Per,Rosenstiel Philip,Schommers Philipp,Suwalski Phillip,de Pablo Raúl,Ferrer Ricard,Bals Robert,Gualtierotti Roberta,Gallego-Durán Rocío,Nieto Rosa,Carpani Rossana,Morilla Rubén,Badalamenti Salvatore,Haider Sammra,Ciesek Sandra,May Sandra,Bombace Sara,Marsal Sara,Pigazzini Sara,Klein Sebastian,Pelusi Serena,Wilfling Sibylle,Bosari Silvano,Volland Sonja,Brunak Søren,Raychaudhuri Soumya,Schreiber Stefan,Heilmann-Heimbach Stefanie,Aliberti Stefano,Ripke Stephan,Dudman Susanne,Wesse Tanja,Zheng Tenghao,Bahmer Thomas,Eggermann Thomas,Illig Thomas,Brenner Thorsten,Pumarola Tomas,Feldt Torsten,Folseraas Trine,Cejudo Trinidad Gonzalez,Landmesser Ulf,Protzer Ulrike,Hehr Ute,Rimoldi Valeria,Monzani Valter,Skogen Vegard,Keitel Verena,Kopfnagel Verena,Friaza Vicente,Andrade Victor,Moreno Victor,Albrecht Wolfgang,Peter Wolfgang,Poller Wolfgang,Farre Xavier,Yi Xiaoli,Wang Xiaomin,Khodamoradi Yascha,Karadeniz Zehra,Latiano Anna,Goerg Siegfried,Bacher Petra,Koehler Philipp,Tran Florian,Zoller Heinz,Schulte Eva C,Heidecker Bettina,Ludwig Kerstin U,Fernández Javier,Romero-Gómez Manuel,Albillos Agustín,Invernizzi Pietro,Buti Maria,Duga Stefano,Bujanda Luis,Hov Johannes R,Lenz Tobias L,Asselta Rosanna,de Cid Rafael,Valenti Luca,Karlsen Tom H,Cáceres Mario,Franke Andre, , , , , ,

Abstract

ABSTRACTGiven the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a highly pleiotropic ∼0.9-Mb inversion polymorphism and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.

Publisher

Cold Spring Harbor Laboratory

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3