Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
Author:
Hansen Justine Y.ORCID, Shafiei GoliaORCID, Markello Ross D.ORCID, Smart KellyORCID, Cox Sylvia M. L., Nørgaard MartinORCID, Beliveau VincentORCID, Wu Yanjun, Gallezot Jean-DominiqueORCID, Aumont ÉtienneORCID, Servaes Stijn, Scala Stephanie G., DuBois Jonathan M.ORCID, Wainstein GabrielORCID, Bezgin GlebORCID, Funck ThomasORCID, Schmitz Taylor W.ORCID, Spreng R. NathanORCID, Galovic MarianORCID, Koepp Matthias J., Duncan John S.ORCID, Coles Jonathan P.ORCID, Fryer Tim D., Aigbirhio Franklin I.ORCID, McGinnity Colm J.ORCID, Hammers AlexanderORCID, Soucy Jean-PaulORCID, Baillet SylvainORCID, Guimond SynthiaORCID, Hietala JarmoORCID, Bédard Marc-André, Leyton MarcoORCID, Kobayashi ElianeORCID, Rosa-Neto PedroORCID, Ganz MelanieORCID, Knudsen Gitte M.ORCID, Palomero-Gallagher NicolaORCID, Shine James M.ORCID, Carson Richard E., Tuominen LauriORCID, Dagher AlainORCID, Misic BratislavORCID
Abstract
AbstractNeurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from >1 200 healthy individuals to construct a whole-brain 3-D normative atlas of 19 receptors and transporters across 9 different neurotransmitter systems. We find that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncover a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we find both expected and novel associations between receptor distributions and cortical thinning patterns across 13 disorders. We replicate all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.
Publisher
Cold Spring Harbor Laboratory
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