Effect of sleeve gastrectomy on sperm quality and fertility on non-obese diabetes diet model rat

Abstract

AbstractBackgroundIn people with diabetes, the effect of sleeve gastrectomy on impaired sperm parameters, hormonal profile and testis tissue remains controversial to some extent.The context and purpose of the studyEffects of sleeve gastrectomy on hormonal profile, sperm parameters, and testis tissue in infertile men with type II diabetes mellitus (TIIDM). This study included thirty two TIIDM that were scheduled with and without sleeve gastrectomy. All rats were taken a sperm analysis, a testis tissue and a serum hormone profile before, 8 weeks after surgery.ResultsThere was a significant correlation between weight loss after sleeve gastrectomy and decreased in glucose profile (p < 0.05). As regards the hormonal profile, testosterone improved significantly after 8 weeks following sleeve gastrectomy. There was a significant increase in sperm count (p < 0.05), and improved sperm morphology during the follow-up after sleeve gastrectomy, also showed that significant changes as improved in testis tissue after surgery.ConclusionSleeve gastrectomy significantly improves testosterone deficiency, testis tissue and sperm count in TIIDM rats. More prospective clinical studies are needed to show how bariatric surgery affects infertility affected by TIIDM patients.