Roles of Polycomb gene EED in pathogenesis and prognosis of acute myeloid leukemia and diffuse large B cell lymphoma

Abstract

AbstractIn this study, we performed correlation analysis of polycomb gene EED and hematologic malignancies using the omics and clinical data of acute myeloid leukemia (LAML) and diffuse large B-Cell lymphoma (DLBC) from TCGA database. We found that: (1) High EED mRNA level was associated with poor prognosis and high CALGB cytogenetics risk of LAML patients. (2) EED mRNA level in DLBC cancer cells was higher than control cells. (3) EED gene expression could be regulated by both copy number alterations and DNA methylation. (4) Additionally, there were different EED co-expression genes nets in the two kinds of hematologic malignancies. In all, we confirmed that there are potential clinical significance of EED gene in pathogenesis and prognosis of hematologic malignancies.