Author:
Zou Di-Xin,Meng Xue-Dan,Xie Ying,Liu Rui,Duan Jia-Lun,Bao Chun-Jie,Liu Yi-Xuan,Du Ya-Fei,Xu Jia-Rui,Luo Qian,Zhang Zhan,Ma Shuang,Yang Wei-Peng,Lin Rui-Chao,Lu Wan-Liang
Abstract
AbstractThe decline of male fertility and its consequences on human populations are important public-health issues. However, there are limited choices for treatment of male infertility. In an attempt to identify a compound that could promote male fertility, we identified and characterized a library of small molecules from an ancient formulation Wuzi Yanzong-Pill, which was used as a folk medicine since the Tang dynasty of China. We found that SB enabled evident repairs in oligoasthenospermia-associated testicular tissue abnormality and in spermatogenesis disruption, resulting in significant improvements of sperm count, mobility, and reproductive ability in oligoasthenospermia mice. Furthermore, SB could alter substantial testicular genes (2033), among which, upregulation of Fst while downregulation of Inhba involved in reproductive signaling pathway could explain its role in enhancing spermatogenesis. The encouraging preclinical data with pharmacokinetics warranted a rapid development of this new class of therapeutic agent. Our finding provides a strong potent drug for treatment of male infertility.
Publisher
Cold Spring Harbor Laboratory
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