Phenol as a breath marker for hemodialysis of chronic kidney disease patients

Abstract

AbstractBackgroundWe aimed to identify biomarkers in breath analysis with MCC-IMS to monitor the haemodialysis for CKD patients fast and non-invasive.Material & methodsSix patients’ breath was analysed via MCC-IMS before and after dialysis and compared to blood plasma samples analysed via UPLC-FLD for potential renal failure biomarkers. Additionally, breath from six healthy control persons was analysed.ResultsPhenol was found as a breath marker for CKD. For three patients the phenol concentration in breath and plasma was elevated before and decreased during dialysis and reached values in the range of healthy control persons.ConclusionThis study shows that the measurement of phenol via breath analysis could be used to monitor the haemodialysis for CKD-patients and might also be usable for the calculation of haemodialysis dose in the future.