Author:
Chen Xiaoping,Hu Wenjia,Ling Jiaxin,Mo Pingzheng,Zhang Yongxi,Jiang Qunqun,Ma Zhiyong,Cao Qian,Deng Liping,Song Shihui,Zheng Ruiying,Gao Shicheng,Ke Hengning,Gui Xien,Lundkvist Åke,Li Jinlin,Lindahl Johanna F,Xiong Yong
Abstract
AbstractObjectivesComorbidities have significant indications for the disease outcome of COVID-19, however which underlying diseases that contribute the most to aggravate the conditions of COVID-19 patients is still largely unknown. SARS-CoV-2 viral clearance is a golden standard for defining the recovery of COVID-19 infections. To dissect the underlying diseases that could impact on viral clearance, we enrolled 106 COVID-19 patients who were hospitalized in the Zhongnan Hospital of Wuhan University, Wuhan, China between Jan 5 and Feb 25, 2020.MethodologyWe comprehensively analyzed demographic, clinical and laboratory data, as well as patient treatment records. Survival analyses with Kaplan-Meier and Cox regression modelling were employed to identify factors influencing the viral clearance negatively.ResultsWe found that increasing age, male gender, and angiotensin-converting enzyme 2 (ACE2) associated factors (including hypertension, diabetes, and cardiovascular diseases) adversely affected the viral clearance. Furthermore, analysis by a random forest survival model pointed out hypertension, cortisone treatment, gender, and age as the four most important variables.ConclusionsWe conclude that patients at old age, males, and/or having diseases associated with high expression of ACE2 will have worse prognosis during a COVID-19 infections.
Publisher
Cold Spring Harbor Laboratory
Cited by
70 articles.
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