Abstract
AbstractThe coronary arteries develop under substantial mechanical loads. However, the role of mechanosensitive ion channels has barely been addressed in this system. Here we demonstrate the expression of the mechanosensitive ion channel PIEZO2 in specific coronary endothelial cell populations during a crucial phase of vascular modeling.Piezo2positive coronary endothelial cells display distinct transcriptional profiles and have mechanically activated ionic currents. Strikingly,Piezo2-/-mouse embryos and mice with human pathogenic variants ofPIEZO2display coronary vessel malformations and left ventricular hyperplasia. We conclude that an optimal balance of PIEZO2 channel function is indispensable for coronary vessel formation, integrity, and remodeling and likely for proper cardiac function.
Publisher
Cold Spring Harbor Laboratory
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