Multi-omics Quality Assessment in Personalized Medicine through EATRIS
Author:
, Alonso-Andrés Patricia, Baldazzi Davide, Chen Qiaochu, Conde Moreno Elisa, Crespo-Toro Lorena, Donner Kati, Džubák Petr, Ekberg Sara, Garcia-Bermejo Maria Laura, Gasparotto Daniela, Ghimire Bishwa, Gloerich Jolein, Habier Janine, Hajdúch Marián, Halder Rashi, Hannula Sari, Lindgren Hanna, Liu Yaqing, Maestro Roberta, Martin Tom, Mattila Pirkko, Najdekr Lukáš, Nazir Kenneth, Niehues Anna, Nieminen Anni I, Nordlund Jessica, Oldoni Emanuela, Övernäs Elin, Palva Aino, Puhka Maija, Quintero Ileana, Ramos-Muñoz Miren Edurne, Rodríguez-Serrano Esperanza Macarena, Saracino Sabrina, Scherer AndreasORCID, Shi Leming, Stanková Jarmila, ’t Hoen Peter-Bram, Tunstall Tanushree, Valenti Beatrice, van Gool Alain, Weiss Marjan, Yadav Bhagwan, Zheng Yuanting, Žižkovičová Patricia
Abstract
ABSTRACTMolecular characterization of a biological sample, e.g., with omics approaches, is fundamental for the development and implementation of personalized and precision medicine approaches. In this context, quality assessment is one of the most critical aspects. Accurate performance and interpretation of omics techniques is based on consensus, harmonization, and standardization of protocols, procedures, data analysis and reference values and materials. EATRIS, the European Infrastructure for Translational Medicine (www.EATRIS.eu), brings together resources and services to support researchers in developing their biomedical discoveries into novel translational tools and interventions for better health outcomes. Here we describe activities of member facilities of EATRIS towards quality assessment of pre-clinical sample processing, clinical omics data generation, multi-omics data integration, and dissemination of the resources in a Multi-Omics Toolbox, the principal deliverable of the EATRIS Plus project for the consolidation of EATRIS towards translational Medicine.
Publisher
Cold Spring Harbor Laboratory
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