ACUTE SEIZURES AFTER SPONTANEOUS INTRACEREBRAL HEMORRHAGE IN YOUNG INDIVIDUALS: 11-YEAR TRENDS AND ASSOCIATION WITH MORTALITY

Abstract

AbstractOBJECTIVETo describe trends in acute seizures (AS) among young individuals with spontaneous intracerebral hemorrhage (sICH) and association with mortality.BACKGROUNDAcute seizures are frequent complications of sICH. The rate of sICH is rising among young Americans (18 to 60 years). Trends in AS incidence in this age group is largely unknown. Further, the association of AS with mortality has not been reported among young Americans.DESIGN/METHODSThe Merative MarketScan® Commercial Claims and Encounters database, for the years 2005 through 2015, served as the data source for this study. This period was chosen as spontaneous ICH incidence increased among young individuals between 2005 and 2015. Our study population included patients aged 18 to 64 years with ICH identified using the International Classification of Diseases, Ninth and Tenth Revision (ICD-9/10) codes 430, 431, 432.0, 432.1, 432.9, I61, I61.0, I61.1, I61.2, I61.3, I61.4, I61.5, I61.6, I61.8, and I61.9, excluding those with a prior diagnosis of seizures (ICD-9/10 codes 345.x,780.3x, G40, G41, and R56.8). We computed yearly AS incidence, mortality (in patients with and without seizures), and analyzed trends. We applied a logistic regression model to determine the independent association of AS with mortality accounting for demographic and clinical variables.RESULTSOf 81,878 sICH patients, 7,611 (9.3%) developed AS. AS incidence increased linearly between 2005 (incidence rate: 8.1%) and 2015 (incidence rate: 11.0%), which represents a 26% relative increase (P for trends <0.0001. In-hospital mortality rate was 14.3% among those who developed AS and 11.5% among those who did not. Between 2005 and 2015, overall, in-hospital mortality decreased from 13.0% to 9.7% among patients without AS but remained unchanged among those with AS. Patients who developed AS were 10% more likely to die than those who did not (OR: 1.10, 95% confidence interval: 1.02-1.18).CONCLUSIONSBetween 2005 and 2015, AS incidence increased by nearly 26% among young Americans with sICH. In-patient mortality remained unchanged among those who developed seizures but declined among those who did not. The occurrence of AS was independently associated with a 10% higher risk of in-hospital death. Future studies will test the benefit of treating AS to reduce mortality after sICH.