The immune map of human body

Abstract

AbstractThe immune system serves as a vital defense mechanism against diseases and infections for human bodies, comprised of a complex network of diverse cells, organs, and tissues. Here, we conduct single-cell deconvolution of 17382 RNA-seq samples from 30 tissues and construct a comprehensive map of the distributions of >1000 different cell states across all the major immune cell types throughout human bodies. This high-resolution immune map covers both sexes and a wide range of ages, enabling interrogation of the immune responses to sex differences and age-related changes. Similarity analysis among the different tissue types depicts the tissue-specific immunity of testis, liver, lung, brain, and kidney besides blood and spleen, and the high immune similarity between breast and adipose tissues for example. This comprehensive immune map may deepen our understanding of human immune system from a holistic perspective.