Platelet hyperactivity in patients of vascular dementia

Abstract

AbstractBackgroundPlatelet-monocyte (PMA) and platelet-neutrophil aggregations (PNA) are critical in causing acute inflammatory reactions favoring vascular dysfunction. However, the precise pathophysiological link between Platelet-leukocyte aggregates and Vascular Dementia (VaD) remains undetermined. Our study aimed to investigate whether platelet hyperresponsiveness is independently associated with a predictor of VaD.MethodsPlatelet from 19 VaD patients and 18 age-matched healthy controls were subjected to different investigations.ResultPMA, PNA, P-selectin externalization, and intracellular free Ca+2([Ca+2i]) flux were evaluated either in whole blood or in platelet-rich plasma. The result revealed that PMA, PNA, P-selectin, and [Ca+2]iwere found to be significantly outnumbered in the VaD group (4.1, 2.8, 2.7, and 2.5 times higher) compared to the control group with p-value <0.001, <0.001, <0.001, and 0.001 at 95% CI = 31.164 to 54.855, 8.653 to 22.793, 35.064 to 94.369 and 8747.015 to 28829.618 respectively.ConclusionPatients with Vascular Dementia have increased platelet leucocyte interaction, and PMA has the most significant prediction of vascular dementia than in subjects of healthy control. Thus, platelets in VaD patients switch to a ‘hyperactive’ phenotype.