Author:
Birling Marie-Christine,Yoshiki Atsushi,Adams David J,Ayabe Shinya,Beaudet Arthur L,Bottomley Joanna,Bradley Allan,Brown Steve DM,Bürger Antje,Bushell Wendy,Chiani Francesco,Chin Hsian-Jean Genie,Christou Skevoulla,Codner Gemma F,DeMayo Francesco J,Dickinson Mary E,Doe Brendan,Donahue Leah Rae,Fray Martin D,Gambadoro Alessia,Gao Xiang,Gertsenstein Marina,Gomez-Segura Alba,Goodwin Leslie O,Heaney Jason D,Hérault Yann,de Angelis Martin Hrabe,Jiang Si-Tse,Justice Monica J,Kasparek Petr,King Ruairidh E,Kühn Ralf,Lee Ho,Lee Young Jae,Liu Zhiwei,Kent Lloyd K C,Lorenzo Isabel,Mallon Ann-Marie,McKerlie Colin,Meehan Terrence F,Newman Stuart,Nutter Lauryl MJ,Oh Goo Taeg,Pavlovic Guillaume,Ramirez-Solis Ramiro,Rosen Barry,Ryder Edward J,Santos Luis A,Schick Joel,Seavitt John R,Sedlacek Radislav,Seisenberger Claudia,Seong Je Kyung,Skarnes William C,Sorg Tania,Steel Karen P,Tamura Masaru,Tocchini-Valentini Glauco P,Leo Wang Chi-Kuang,Wardle-Jones Hannah,Wattenhofer-Donzé Marie,Wells Sara,Willis Brandon J,Wood Joshua A,Wurst Wolfgang,Xu Ying,Teboul Lydia,Murray Stephen A,
Abstract
AbstractThe International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for over 5,000 genes from targeted embryonic stem cells on the C57BL/6N genetic background. This includes 2,850 null alleles for which no equivalent mutant mouse line exists, 2,987 novel conditional-ready alleles, and 4,433 novel reporter alleles. This nearly triples the number of genes with reporter alleles and almost doubles the number of conditional alleles available to the scientific community. When combined with more than 30 years of community effort, the total mutant allele mouse resource covers more than half of the genome. The extensively validated collection is archived and distributed through public repositories, facilitating availability to the worldwide biomedical research community, and expanding our understanding of gene function and human disease.
Publisher
Cold Spring Harbor Laboratory