Author:
Petruzzelli Michele,Wagner Erwin F.
Abstract
Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the adipose tissue. This systemic syndrome, termed cancer-associated cachexia (CAC), is a major cause of morbidity and mortality. While once attributed solely to decreased food intake, the present description of cancer cachexia is a disorder of multiorgan energy imbalance. Here we review the molecules and pathways responsible for metabolic dysfunction in CAC and the ideas that led to the current understanding.
Funder
Spanish Ministry of Economy
European Research Council
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
224 articles.
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