Metabolic analysis in intact human-derived cerebral organoids by high-resolution magic-angle spinning NMR spectroscopy

Author:

Castilla Bolanos Maria AlejandraORCID,Chinchalongporn Vorapin,Biswas Rajshree Ghosh,Bailey Colleen,Wu Maggie,Soong Ronald,Saleh Fermisk,Simpson Andre,Schuurmans Carol,Near Jamie

Abstract

AbstractHuman-derived cerebral organoids (COs) are an emerging model system for the study of human neural development and physiology. Here, we describe the assessment of metabolism in human-derived CO’s using high-resolution magic-angle spinning (HR-MAS) NMR spectroscopy. Metabolic changes during development are assessed by studying COs at various stages of maturity. Our results suggest that COs exhibit a metabolic profile similar toin vivohuman brain metabolism, albeit with a few notable metabolic differences.

Publisher

Cold Spring Harbor Laboratory

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