Author:
Kumar Mukesh,Has Canan,Lam-Kamath Khanh,Ayciriex Sophie,Dewett Deepshe,Bashir Mhamed,Poupault Clara,Schuhmann Kai,Knittelfelder Oskar,Raghuraman Bharath Kumar,Ahrends Robert,Rister Jens,Shevchenko Andrej
Abstract
AbstractTheDrosophila melanogastereye is a popular model to elucidate the molecular mechanisms that underlie the structure and function of the eye as well as the causes of retinopathies. For instance, theDrosophilaeye has been used to investigate the impacts of ageing and environmental stresses such as light-induced damage or dietary deficiencies. Moreover, large-scale screens have isolated genes whose mutation causes morphological and functional ocular defects, which includes key components of the phototransduction cascade. However, the proteome of theDrosophilaeye is poorly characterized. Here, we used GeLC-MS/MS to quantify 3516 proteins he adultDrosophila melanogastereye and provide a generic and expandable resource for further genetic, pharmacological, and dietary studies.
Publisher
Cold Spring Harbor Laboratory