Ribosomal protein control of hematopoietic stem cell transformation through direct, non-canonical regulation of metabolism

Author:

Harris Bryan,Singh Dinesh K.,Verma Monika,Fahl Shawn P.,Rhodes Michele,Sprinkle Shanna R.,Wang Minshi,Zhang Yong,Perrigoue Jaqueline,Kessel Rachel,Peri Suraj,West Joshua,Giricz Orsi,Boultwood Jacqueline,Pellagatti Andrea,Ramesh KH,Montagna Cristina,Pradhan Kith,Tyner Jeffrey W.,Kennedy Brian K.,Holinstat MichaelORCID,Steidl Ulrich,Sykes Stephen,Verma Amit,Wiest David L.

Abstract

SummaryWe report here that expression of the ribosomal protein, RPL22, is frequently reduced in human myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML); reduced RPL22 expression is associated with worse outcomes. Mice null for Rpl22 display characteristics of an MDS-like syndrome and develop leukemia at an accelerated rate. Rpl22-deficient mice also display enhanced hematopoietic stem cell (HSC) self-renewal and obstructed differentiation potential, which arises not from reduced protein synthesis but from increased expression of the Rpl22 target, ALOX12, an upstream regulator of fatty acid oxidation (FAO). The increased FAO mediated by Rpl22-deficiency also persists in leukemia cells and promotes their survival. Altogether, these findings reveal that Rpl22 insufficiency enhances the leukemia potential of HSC via non-canonical de-repression of its target, ALOX12, which enhances FAO, a process that may serve as a therapeutic vulnerability of Rpl22 low MDS and AML leukemia cells.HighlightsRPL22 insufficiency is observed in MDS/AML and is associated with reduced survivalRpl22-deficiency produces an MDS-like syndrome and facilitates leukemogenesisRpl22-deficiency does not impair global protein synthesis by HSCRpl22 controls leukemia cell survival by non-canonical regulation of lipid oxidationeTOC:Rpl22 controls the function and transformation potential of hematopoietic stem cells through effects on ALOX12 expression, a regulator of fatty acid oxidation.

Publisher

Cold Spring Harbor Laboratory

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