Immunoglobulin A as a key immunological molecular signature of post-COVID-19 conditions-Reference-Cited by-同舟云学术

Immunoglobulin A as a key immunological molecular signature of post-COVID-19 conditions

Published:2023-05-16 Issue: Volume: Page:
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Author:

Sousa Graziele F.,Carpes Raphael M.,Silva Carina A. O.,Pereira Marcela E. P.,Silva Amanda C. V. F.,Coelho Viktoria A. G. S.,Costa Evenilton P.,Mury Flávia B.,Gestinari Raquel S.,Menezes Jackson S.,Silva Manuela L.,Nepomuceno-Silva José L.,Tanuri Amilcar,Júnior Orlando C. F.,Monteiro-de-Barros Cintia^ORCID

Abstract

AbstractCOVID-19 has infected humans worldwide, causing millions of deaths or prolonged symptoms in survivors. The transient or persistent symptoms after SARS-CoV-2 infection have been defined as post-COVID-19 conditions (PCC). We conducted a study of 151 Brazilian PCC patients to analyze symptoms and immunoglobulin profiles, taking into account gender, vaccination, hospitalization and age. Fatigue and myalgia were the most common symptoms and lack of vaccination, hospitalization, and neuropsychiatric and metabolic comorbidities were relevant for the development of PCC. Analysis of serological immunoglobulins showed that IgA was higher in PCC patients, especially in the adult and elderly groups. Also, non-hospitalized and hospitalized PCC patients produced high and similar levels of IgA. Our results indicated that the detection of IgA antibodies against SARS-CoV-2 during the course of the disease could be associated with the development of PCC and may be an immunological signature to predict prolonged symptoms in COVID-19 patients.

Publisher

Cold Spring Harbor Laboratory

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