Abstract
AbstractSerotonergic circuits in the central nervous system play important roles in regulating mood and behavior, yet the functions of peripheral serotonergic neurons are less understood. Here, we engineered mice lacking the serotonin-producing enzymeTph2in peripheral neurons but with intactTph2in central neurons. In contrast to mice lackingTph2in all neurons, mice lackingTph2in peripheral serotonergic neurons did not exhibit increased territorial aggression. However, similar to the total bodyTph2KO mice, the conditional KO animals, exhibited reduced gut motility and decreased anxiety-like behavior. These observations reveal that peripheral serotonergic neurons contribute to control of intestinal motility and anxiety-like behavior and suggest that therapeutics targeting this subset of peripheral neurons could be beneficial.
Publisher
Cold Spring Harbor Laboratory
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