Author:
Chorin Ehud,Dai Matthew,Shulman Eric,Wadhwani Lalit,Roi-Bar-Cohen ,Barbhaiya Chirag,Aizer Anthony,Holmes Douglas,Bernstein Scott,Spinelli Michael,Park David S.,Chinitz Larry A.,Jankelson Lior
Abstract
AbstractWe report the change in the QT interval in 84 adult patients with SARS-CoV-2 infection treated with Hydroxychloroquine/Azithromycin combination. QTc prolonged maximally from baseline between days 3 and 4. in 30% of patients QTc increased by greater than 40ms. In 11% of patients QTc increased to >500 ms, representing high risk group for arrhythmia. The development of acute renal failure but not baseline QTc was a strong predictor of extreme QTc prolongation.
Publisher
Cold Spring Harbor Laboratory
Reference16 articles.
1. World Health Organization data, 03/28/2020.
2. Gautret P , Lagier J-C , Parola P , Meddeb L , Mailhe M , Doudier B , Courjon J , Giordanengo V , Vieira VE and Dupont HT . Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents. 2020:105949.
3. Chronic Hydroxychloroquine Use Associated with QT Prolongation and Refractory Ventricular Arrhythmia
4. Suspected hydroxychloroquine-associated QT-interval prolongation in a patient with systemic lupus erythematosus;JCR: Journal of Clinical Rheumatology,2013
5. Azithromycin-Induced Torsade De Pointes
Cited by
67 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献