Author:
Mishra Divya,Mishra Ashish,Singh M.P.
Abstract
AbstractCancer is one of the deadliest diseases developed through tumorigenesis and could be fatal if reached at metastatic phase. The novality of present investigation is to explore the prognostic biomarkers in hepatocellular carcinoma (HCC) that could develop glioblastoma multiforme (GBM) due to metastasis. The analysis was done using RNA-Seq datasets for both HCC (PRJNA494560 and PRJNA347513) and GBM (PRJNA494560 and PRJNA414787) from Gene Expression Omnibus (GEO). This study identified 13 hub genes found to be overexpressed in both GBM and HCC. Promoter methylation study showed these genes to be hypomethylated. Validation through genetic alteration and missense mutations resulted in chromosomal instability leading to improper chromosome segregation causing aneuploidy. A 13-gene predictive model was obtained and validated using KM plot. These hub genes could be prognostic biomarkers and potential therapeutic targets, inhibition of which could suppress tumorigenesis and metastasis.
Publisher
Cold Spring Harbor Laboratory
Reference84 articles.
1. The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
2. The mitotic checkpoint in cancer and aging: what have mice taught us?
3. New mini- zincin structures provide a minimal scaffold for members of this metallopeptidase superfamily
4. Aurora kinase A as a rational target for therapy in glioblastoma: Laboratory investigation’;Journal of Neurosurgery: Pediatrics,2010
5. Bayard, Q. , Meunier, L. , Peneau, C. , Renault, V. , Shinde, J. , Nault, J. C. , Mami, I. , Couchy, G. , Amaddeo, G. , Tubacher, E. , Bacq, D. , Meyer, V. , La Bella, T. , Debaillon-Vesque, A. , Bioulac-Sage, P. , Seror, O. , Blanc, J. F. , Calderaro, J. , Deleuze, J. F. , & Letouzé, E. (2018) ‘Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress’. Nature Communications, vol. 9 No. 1. https://doi.org/10.1038/s41467-018-07552-9