Abstract
The brain makes decisions by accumulating evidence until there is enough to stop and choose. Neural mechanisms of evidence accumulation are well established in association cortex, but the site and mechanism of termination is unknown. Here, we elucidate a mechanism for termination by neurons in the primate superior colliculus. We recorded simultaneously from neurons in lateral intraparietal cortex (LIP) and the superior colliculus (SC) while monkeys made perceptual decisions, reported by eye-movements. Single-trial analyses revealed distinct dynamics: LIP tracked the accumulation of evidence on each decision, and SC generated one burst at the end of the decision, occasionally preceded by smaller bursts. We hypothesized that the bursts manifest a threshold mechanism applied to LIP activity to terminate the decision. Focal inactivation of SC produced behavioral effects diagnostic of an impaired threshold sensor, requiring a stronger LIP signal to terminate a decision. The results reveal the transformation from deliberation to commitment.
Publisher
Cold Spring Harbor Laboratory
Reference65 articles.
1. Acerbi, L. , Ma, W.J. , 2017. Practical bayesian optimization for model fitting with bayesian adaptive direct search. Advances in neural information processing systems 30.
2. Corticocortical connections of anatomically and physiologically defined subdivisions within the inferior parietal lobule
3. Unraveling circuits of visual perception and cognition through the superior colliculus;Neuron,2021
4. Attention, Intention, and Priority in the Parietal Lobe
5. Blackburn, S. , 2008. The Oxford Dictionary of Philosophy (2 ed.). Oxford: Oxford University Press.
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