Author:
Simon Katherine E.,Russell Katharine,Mondino Alejandra,Yang Chin-Chieh,Case Beth C,Anderson Zachary,Whitley Christine,Griffith Emily,Gruen Margaret E.,Olby Natasha J.
Abstract
AbstractAge-related decline in mobility and cognition are associated with cellular senescence and NAD+ depletion in dogs and people. A combination of a novel NAD+ precursor and senolytic, LY-D6/2 was examined in this randomized controlled trial. Seventy dogs were enrolled and allocated into placebo, low or full dose groups. Primary outcomes were change in cognitive impairment measured with the owner-reported Canine Cognitive Dysfunction Rating (CCDR) scale and change in activity measured with physical activity monitors. Fifty-nine dogs completed evaluations at the three-month primary endpoint, and 51 reached the six-month secondary endpoint. There was a significant difference in CCDR score across treatment groups from baseline to the primary endpoint (p=0.02) with the largest decrease in the full dose group. There were no significant differences between groups in changes in measured activity. However, the proportion of dogs that improved in frailty and owner-reported activity levels and happiness was higher in the full dose group than other groups. Adverse events occurred equally across groups. All groups showed improvement in cognition, frailty, and activity suggesting placebo effect and benefits of trial participation. We conclude that LY-D6/2 significantly improves owner-assessed cognitive function and may have broader effects on frailty, activity and happiness as reported by owners.
Publisher
Cold Spring Harbor Laboratory
Reference88 articles.
1. Ageing: it’s a dog’s life;Current Biology,2013
2. Longevity and mortality in Kennel Club registered dog breeds in the UK in 2014;Canine genetics and epidemiology,2018
3. Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations?;Aging and Cancer,2022
4. Creevy, K. E. , Austad, S. N. , Hoffman, J. M. , O’Neill, D. G. , & Promislow, D. E . The Companion Dog as a Model for the Longevity Dividend. Cold Spring Harbor perspectives in medicine. 6, a026633 (2016).
5. Jin, K. , Hoffman, J. M. , Creevy, K. E. , O’Neill, D. G. , & Promislow, D. E . Multiple morbidities in companion dogs: a novel model for investigating age-related disease. Pathobiology of aging & age related diseases. 6, 33276 (2016)