Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH-Reference-Cited by-同舟云学术

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Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH

Published:2023-01-16 Issue: Volume: Page:
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Author:

Ali Md Khadem,Zhao Lan,Perez Vinicio de Jesus^ORCID,Nicolls Mark R.,Spiekerkoetter Edda F.

Abstract

AbstractELK3 is upregulated in blood and pulmonary vascular cells of PAH patients and may play a significant role in PAH potentially through modulating BMPR2 signaling.

Publisher

Cold Spring Harbor Laboratory

Reference10 articles.

1. Promising therapeutic approaches in pulmonary arterial hypertension;Curr Opin Pharmacol,2021

2. FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension;Am J Respir Crit Care Med,2019

3. Expression of endothelin type B receptors (EDNRB) on smooth muscle cells is controlled by MKL2, ternary complex factors, and actin dynamics;Am J Physiol Cell Physiol,2018

4. ELK3 Suppresses Angiogenesis by Inhibiting the Transcriptional Activity of ETS-1 on MT1-MMP

5. Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome;Am J Respir Crit Care Med,2020

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