Author:
Peri Suraj,Navarro J. Daniel,Amanchy Ramars,Kristiansen Troels Z.,Jonnalagadda Chandra Kiran,Surendranath Vineeth,Niranjan Vidya,Muthusamy Babylakshmi,Gandhi T.K.B.,Gronborg Mads,Ibarrola Nieves,Deshpande Nandan,Shanker K.,Shivashankar H.N.,Rashmi B.P.,Ramya M.A.,Zhao Zhixing,Chandrika K.N.,Padma N.,Harsha H.C.,Yatish A.J.,Kavitha M.P.,Menezes Minal,Choudhury Dipanwita Roy,Suresh Shubha,Ghosh Neelanjana,Saravana R.,Chandran Sreenath,Krishna Subhalakshmi,Joy Mary,Anand Sanjeev K.,Madavan V.,Joseph Ansamma,Wong Guang W.,Schiemann William P.,Constantinescu Stefan N.,Huang Lily,Khosravi-Far Roya,Steen Hanno,Tewari Muneesh,Ghaffari Saghi,Blobe Gerard C.,Dang Chi V.,Garcia Joe G.N.,Pevsner Jonathan,Jensen Ole N.,Roepstorff Peter,Deshpande Krishna S.,Chinnaiyan Arul M.,Hamosh Ada,Chakravarti Aravinda,Pandey Akhilesh
Abstract
Human Protein Reference Database (HPRD) is an object database that integrates a wealth of information relevant to the function of human proteins in health and disease. Data pertaining to thousands of protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, and subcellular localization were extracted from the literature for a nonredundant set of 2750 human proteins. Almost all the information was obtained manually by biologists who read and interpreted >300,000 published articles during the annotation process. This database, which has an intuitive query interface allowing easy access to all the features of proteins, was built by using open source technologies and will be freely available at http://www.hprd.org to the academic community. This unified bioinformatics platform will be useful in cataloging and mining the large number of proteomic interactions and alterations that will be discovered in the postgenomic era.
Publisher
Cold Spring Harbor Laboratory
Subject
Genetics(clinical),Genetics