Decreased Fatty Acid β-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice

Author:

Nakajima Takero12,Yang Yang13,Lu Yu1,Kamijo Yuji14,Yamada Yosuke14,Nakamura Kozo25,Koyama Masahiro5,Yamaguchi Shohei5,Sugiyama Eiko6,Tanaka Naoki12,Aoyama Toshifumi1

Affiliation:

1. Department of Metabolic Regulation, Shinshu University Graduate School of Medicine

2. Research Center for Agricultural Food Industry, Shinshu University

3. Department of Cardiology, The Third Hospital of Hebei Medical University

4. Department of Nephrology, Shinshu University School of Medicine

5. Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University

6. Department of Nutritional Science, Nagano Prefectural College

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference44 articles.

1. Alwayn, I.P., Javid, P.J., Gura, K.M., Nosé, V., Ollero, M. & Puder, M. (2004) Do polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREPB-1 suppression or by correcting essential fatty acid deficiency. Hepatology, 39, 1176-1177.

2. Aoyama, T., Hardwick, J.P., Imaoka, S., Funae, Y., Gelboin, H.V. & Gonzalez, F.J. (1990) Clofibrate-inducible rat hepatic P450s IVA1 and IVA3 catalyze the ω- and (ω-1)-hydroxylation of fatty acids and the ω-hydroxylation of prostaglandins E1 and F2α. J. Lipid Res., 31, 1477-1482.

3. Aoyama, T., Peters, J.M., Iritani, N., Nakajima, T., Furihata, K., Hashimoto, T. & Gonzalez, F.J. (1998) Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα). J. Biol. Chem., 273, 5678-5684.

4. Aoyama, T., Yamano, S., Waxman, D.J., Lapenson, D.P., Meyer, U.A., Fischer, V., Tyndale, R., Inaba, T., Kalow, W. & Gelboin, H.V. (1989) Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J. Biol. Chem., 264, 10388-10395.

5. Arendt, B.M., Comelli, E.M., Ma, D.W., Lou, W., Teterina, A., Kim, T., Fung, S.K., Wong, D.K., McGilvray, I., Fischer, S.E. & Allard, J.P. (2015) Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids. Hepatology, 61, 1565-1578.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3