The FOXL2 Mutation (c.402C>G) in Adult-Type Ovarian Granulosa Cell Tumors of Three Japanese Patients: Clinical Report and Review of the Literature

Author:

Takahashi Akimasa1,Kimura Fuminori1,Yamanaka Akiyoshi1,Takebayashi Akie1,Kita Nobuyuki1,Takahashi Kentaro1,Murakami Takashi1

Affiliation:

1. Department of Obstetrics and Gynecology, Shiga University of Medical Science

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference42 articles.

1. Ahrens, T., Pertz, O., Haussinger, D., Fauser, C., Schulthess, T. & Engel, J. (2002) Analysis of heterophilic and homophilic interactions of cadherins using the c-Jun/c-Fos dimerization domains. J. Biol. Chem., 277, 19455-19460.

2. Al-Agha, O.M., Huwait, H.F., Chow, C., Yang, W., Senz, J., Kalloger, S.E., Huntsman, D.G., Young, R.H. & Gilks, C.B. (2011) FOXL2 is a sensitive and specific marker for sex cord-stromal tumors of the ovary. Am. J. Surg. Pathol., 35, 484-494.

3. Alexiadis, M., Eriksson, N., Jamieson, S., Davis, M., Drummond, A.E., Chu, S., Clyne, C.D., Muscat, G.E. & Fuller, P.J. (2011) Nuclear receptor profiling of ovarian granulosa cell tumors. Horm. Cancer, 2, 157-169.

4. Benayoun, B.A., Anttonen, M., L’Hôte, D., Bailly-Bechet, M., Andersson, N., Heikinheimo, M. & Veitia, R.A. (2013) Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation. Oncogene, 32, 2739-2746.

5. Benayoun, B.A., Caburet, S., Dipietromaria, A., Georges, A., D’Haene, B., Pandaranayaka, P.J., L’Hôte, D., Todeschini, A.L., Krishnaswamy, S., Fellous, M., De Baere, E. & Veitia, R.A. (2010) Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G). PLoS One, 5, e8789.

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