Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases

Author:

Suzuki Takehiro12,Yamaguchi Hiroaki3,Kikusato Motoi4,Matsuhashi Tetsuro5,Matsuo Akihiro2,Sato Takeya6,Oba Yuki2,Watanabe Shun2,Minaki Daichi7,Saigusa Daisuke8,Shimbo Hiroko9,Mori Nobuyoshi10,Mishima Eikan2,Shima Hisato2,Akiyama Yasutoshi2,Takeuchi Yoichi2,Yuri Akinori11,Kikuchi Koichi122,Toyohara Takafumi2,Suzuki Chitose2,Kohzuki Masahiro10,Anzai Jun-ichi7,Mano Nariyasu3,Kure Shigeo5,Yanagisawa Teruyuki6,Tomioka Yoshihisa11,Toyomizu Masaaki4,Ito Sadayoshi2,Osaka Hitoshi13,Hayashi Ken-ichiro14,Abe Takaaki15122

Affiliation:

1. Renal Division, Brigham and Women’s Hospital and Harvard Medical School

2. Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine

3. Department of Pharmaceutical Sciences, Tohoku University Hospital

4. Animal Nutrition, Life Sciences, Graduate School of Agricultural Science, Tohoku University

5. Division of Pediatrics, Tohoku University Graduate School of Medicine

6. Department of Molecular Pharmacology, Tohoku University Graduate School of Medicine

7. Graduate School of Pharmaceutical Sciences, Tohoku University

8. Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University

9. Clinical Research Institute, Kanagawa Children’s Medical Center

10. Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine Sendai

11. Laboratory of Oncology, Pharmacy Practice and Sciences, Tohoku University Graduate School of Pharmaceutical Sciences

12. Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine

13. Division of Pediatrics, Jichi Medical University

14. Department of Biochemistry, Okayama University of Science

15. Department of Medical Science, Tohoku University Graduate School of Biomedical Engineering

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference27 articles.

1. Abu Sinna, G. (1983) The effect of the plant hormone indole-3-acetic acid and chemically related compounds on the growth of mouse fibroblast 3T3 cells. Comp. Biochem. Physiol. C, 74, 433-436.

2. Avula, S., Parikh, S., Demarest, S., Kurz, J. & Gropman, A. (2014) Treatment of mitochondrial disorders. Curr. Treat. Options Neurol., 16, 292.

3. Carelli, V., La Morgia, C. & Sadun, A.A. (2013) Mitochondrial dysfunction in optic neuropathies: animal models and therapeutic options. Curr. Opin. Neurol., 26, 52-58.

4. Che, R., Yuan, Y., Huang, S. & Zhang, A. (2014) Mitochondrial dysfunction in the pathophysiology of renal diseases. Am. J. Physiol. Renal Physiol., 306, F367-F378.

5. Chung, K.T., Anderson, G.M. & Fulk, G.E. (1975) Formation of indoleacetic acid by intestinal anaerobes. J. Bacteriol., 124, 573-575.

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