Affiliation:
1. Department of Biology, College of Education for Pure sciences, University of Basrah, Basrah, Iraq.
Abstract
Irritable Bowel Syndrome (IBS) is a common disorder of the large intestine. This study was designed to Estimation of interleukin 8 and 10 in human suffering from irritable bowel syndrome and the relationship with age and period of disease. A total of 88 men participated in this study, including 57 men as patient, and 31 as healthy, who were collected from Al-Fayhaa Hospital in Basrah. The patients was classified according to age into (30-40), (41-50) and (51-60), and according to the disease period into (1-5) and (6-10) years. The healthy were aged (30-60 years).IL-8 and IL-10 were measured using ELISA technique and The data statistical analysis software (One-way Anova) and Mann-Watny test. The results showed a significant increase of interleukin-8 (IL-8) for patients at P≤0.001, while there was a significant decrease in the level of interleukin-10 (IL-10) at P≤0.001. Regarding the age groups, the results did not show variation of IL-8 levels .while, the level of IL-10 in the (41-50 years) was significantly lower. As for the relationship between the duration of the disease there is no significant differences. The study concluded that inflammations play a role in inducing irritable bowel syndrome and the age group (41-50) was more affected.
Publisher
College of Education for Pure Science, University of Basrah
Reference69 articles.
1. M. Raetz, H. S-h, CL Wilhelm, D .Kirkland, A. Benson, CR. Sturge and F. Yarovinsky, Nat Immunol 14(2), 136 (2013). https://doi.org/10.1038/ni.2508
2. E. Brian, K. Nihal and J. Patel 65, 829 (2017).
3. M.A.Atiyah and S.Abbas , Inter J of Psych Rehab 24(9), 4029 (2021).
4. S. Alatab , S. G. Sepanlou, K .Ikuta, H. Vahedi , C .Bisignano, S. Safiri and M. Naghavi, Lancet gastroentero hepatol 5(1), 17 (2020).
5. H.AJ.Alkatrani and M.A.Mohammad , Basrah J of Surg 28(1), 25 (2022).