Synthesis and Crystal Structure of Ethyl 7-Chloro-3-Amino-9-(4-Bromophenyl)Thieno-[3,2-b]Benzothiazine 4,4-Dioxide 2-Carboxylate-Reference-Cited by-同舟云学术

Synthesis and Crystal Structure of Ethyl 7-Chloro-3-Amino-9-(4-Bromophenyl)Thieno-[3,2-b]Benzothiazine 4,4-Dioxide 2-Carboxylate

Published:2007-01 Issue:1 Volume:2007 Page:16-18
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Charris Jaime¹,Barazarte Arthur¹,Ferrer Rosa¹,Camacho José¹,Gamboa Neira²,Rodrigues Juan²,Atencio Reinaldo³,González Teresa³

Affiliation:

1. Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Apartado 47206, Los Chaguaramos, 1041-A Caracas, Venezuela

2. Laboratorio de Bioquímica, Facultad de Farmacia, Universidad Central de Venezuela, Apartado 47206, Los Chaguaramos, 1041-A Caracas, Venezuela

3. Laboratorio de Síntesis y Caracterización de Nuevos Materiales, Instituto Venezolano de Investigaciones Científicas (IVIC) Apartado 21827, Caracas, 1020-A, Venezuela

Abstract

The X-ray crystal structure of 7-chloro-3-amino-9-(4-bromophenyl)thieno-[3,2-b]benzothiazine 4,4-dioxide 2-carboxylate 1 is determined. The thiophene ring and the exocyclic ester group adopt a co-planar conformation, which is stabilised by an intramolecular hydrogen bond. The moderate antimalarial activity shown by this compound appears to be related to the formation of such an intramolecular N–H···O =C hydrogen bond.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823407780199504

Reference10 articles.

1. Recent Advances in the Search for Newer Antimalarial Agents

2. Synthesis of quinolinyl chalcones and evaluation of their antimalarial activity

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