Synthesis of Novel Chromenes as Cytotoxic Agents-Reference-Cited by-同舟云学术

Synthesis of Novel Chromenes as Cytotoxic Agents

Published:2013-02 Issue:2 Volume:37 Page:110-114
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Kandeel Manal M.¹,Kamal Aliaa M.¹,Abdelall Eman K.A.²,Elshemy Heba A.H.²

Affiliation:

1. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

2. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Egypt

Abstract

Novel substituted chromenes, chromenopyrimidines and chromenotriazolopyrimidines were synthesised to explore their anticancer activity. Several compounds were evaluated for their antitumour activity, most of them revealed promising cytotoxic activity against breast cancer cell line MCF-7 in comparison to colchicine as positive control.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751913X13573228322518

Reference15 articles.

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4. A novel QSAR model for predicting induction of apoptosis by 4-aryl-4H-chromenes

5. Novel TOPP descriptors in 3D-QSAR analysis of apoptosis inducing 4-aryl-4H-chromenes: Comparison versus other 2D- and 3D-descriptors

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