Synthesis of 24(28)-Methylene-1α-Hydroxyvitamin D3, a Novel Vitamin D3 Analogue-Reference-Cited by-同舟云学术

Synthesis of 24(28)-Methylene-1α-Hydroxyvitamin D3, a Novel Vitamin D3 Analogue

Published:2014-04 Issue:4 Volume:38 Page:231-235
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Guo Wei¹,Fang Zhijie¹,Li Hongliang¹,Liu Yanan¹

Affiliation:

1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P.R. China

Abstract

24(28)-Methylene-1α-hydroxyvitamin D3 was synthesised in 13 steps from vitamin D2. The key step of the synthesis involved the Wittig–Horner olefination of a nor-vitamin D2 aldehyde with diethylphosphono-3-methyl-2-butanone. The resulting enone was followed by reduced methylenation, photoisomerisation and deprotection then gave the target compound.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751914X13941144023496

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