Aphidicolin: Its Chemistry and Biosynthesis

Abstract

1. Introduction 2. Naturally occurring aphidicolanes 3. The chemistry of aphidicolin 4. Synthesis 5. Biosynthesis 6. References The occurrence and structure of the biologically active tetracyclic diterpenoid aphidicolin and related aphidicolane natural products, together with their chemistry, their molecular rearrangements and their biosynthesis, are reviewed.