First Synthesis of 2-Ferrocenoyl-3-Methylbenzofuran Derivatives-Reference-Cited by-同舟云学术

First Synthesis of 2-Ferrocenoyl-3-Methylbenzofuran Derivatives

Published:2015-02 Issue:2 Volume:39 Page:82-85
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Zhuoma Bairenqing¹,Li Yang¹,Gao Wentao¹

Affiliation:

1. Institute of Superfine Chemicals, Bohai University, Keji Street, Jinzhou, 121000, P.R. China

Abstract

The incorporation of the 3-methylbenzofuran moiety into the ferrocene nucleus leading to a series of structurally novel hybrids 2-ferrocenoyl-3-methylbenzofuran derivatives has been achieved in good yields of 76-85% through the one-pot Rap-Stoermer reaction of 1-chloroacetylferrocene with 2′-hydroxyacetophenones in refluxing CH3CN with the presence of K2CO3 as base and PEG-400 as catalyst. These newly-synthesised compounds could be good candidates for the development of compounds for use in medicinal chemistry.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751915X14214277697280

Reference28 articles.

1. A New Type of Organo-Iron Compound

2. At Least 60 Years of Ferrocene: The Discovery and Rediscovery of the Sandwich Complexes

3. Bioorganometallic Chemistry of Ferrocene

4. New Principles in Medicinal Organometallic Chemistry

5. Metallocene-based antimalarials: An exploration into the influence of the ferrocenyl moiety on in vitro antimalarial activity in chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum

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