An Optimised Procedure for PTFE Phase Vanishing Reactions: An Improved reaction Design and the use of Reagents Adsorbed on Silica-Reference-Cited by-同舟云学术

An Optimised Procedure for PTFE Phase Vanishing Reactions: An Improved reaction Design and the use of Reagents Adsorbed on Silica

Published:2015-10 Issue:10 Volume:39 Page:574-581
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Parsons Brendon A.¹²,Smith Olivia Lin¹,Dragojlovic Veljko¹

Affiliation:

1. Wilkes Honors College of Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL 33458, USA

2. Present address address: Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA

Abstract

While the phase-vanishing (PV)-PTFE reaction design works well with a broad range of substrates and reaction conditions, there are occasional problems. A description of the problems and their importance, including their effects on the reaction outcome and ways to address them, are discussed. Details of an improved design, a hybrid of previously reported PV-PTFE and solvent-free PV-PTFE designs, is presented, as well as the use of silica-supported reagents.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751915X14416158938073

Reference26 articles.

1. Phase-Vanishing Reactions that Use Fluorous Media as a Phase Screen. Facile, Controlled Bromination of Alkenes by Dibromine and Dealkylation of Aromatic Ethers by Boron Tribromide

2. Fluorous Solvent as a New Phase-Screen Medium between Reagents and Reactants in the Bromination and Chlorination of Alcohols

3. Association of Fluorous “Phase-Vanishing” Method with Visible-Light Activation in Benzylic Bromination by Bromine

4. A Photoirradiative Phase-Vanishing Method: Efficient Generation of HBr from Alkanes and Molecular Bromine and Its Use for Subsequent Radical Addition to Terminal Alkenes