Regioselective Ring-Opening of Epoxides by Carbazole: A Direct Preparation of Novel N-(β-Hydroxyalkyl)Carbazoles-Reference-Cited by-同舟云学术

Regioselective Ring-Opening of Epoxides by Carbazole: A Direct Preparation of Novel N-(β-Hydroxyalkyl)Carbazoles

Published:2016-03 Issue:3 Volume:40 Page:137-140
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Soltani Rad Mohammad Navid¹,Behrouz Somayeh¹,Ahrari Samira¹

Affiliation:

1. Medicinal Chemistry Research Laboratory, Department of Chemistry, Shiraz University of Technology, Shiraz 71555-313, Iran

Abstract

The influence of various parameters including solvent, base and temperature on the reaction between carbazole and epoxides was studied. This led to the development of a regioselective ring-opening of epoxides by the potassium salt of carbazole in DMSO at 100 °C which is a straightforward way to prepare new N-(β-hydroxyalkyl)carbazoles in good to excellent yields. Fifteen new compounds are described.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751916X14538054606043

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