Fecal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) RNA Is Associated With Decreased Coronavirus Disease 2019 (COVID-19) Survival-Reference-Cited by-同舟云学术

Fecal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) RNA Is Associated With Decreased Coronavirus Disease 2019 (COVID-19) Survival

Published:2021-07-10 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Das Adhikari Upasana¹²,Eng George²³⁴,Farcasanu Mara¹²,Avena Laura E⁵,Choudhary Manish C⁶,Triant Virginia A⁷,Flagg Meaghan¹,Schiff Abigail E¹²,Gomez Isabella¹,Froehle Leah M¹,Diefenbach Thomas J¹,Ronsard Larance¹,Lingwood Daniel¹,Lee Grace C⁸,Rabi Seyed Alireza⁸,Erstad Derek⁸,Velmahos George⁸,Li Jonathan Z²⁶,Hodin Richard⁸,Stone James R²³^ORCID,Honko Anna N⁵,Griffiths Anthony⁵,Yilmaz Ömer H²³⁴,Kwon Douglas S¹²⁷^ORCID

Affiliation:

1. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, Massachusetts, USA

2. Harvard Medical School, Boston, Massachusetts, USA

3. Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

4. Koch Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

5. Department of Microbiology and National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, Massachusetts, USA

6. Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA

7. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA

8. Division of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA

Abstract

Abstract The clinical significance of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) RNA in stool remains uncertain. We found that extrapulmonary dissemination of infection to the gastrointestinal tract, assessed by the presence of SARS-CoV-2 RNA in stool, is associated with decreased coronavirus disease 2019 (COVID-19) survival. Measurement of SARS-CoV-2 RNA in stool may have utility for clinical risk assessment.

Funder

National Institutes of Health

Ragon Insitute of MGH, MIT and Harvard

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab623/39594505/ciab623.pdf

Reference12 articles.

1. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China;Huang;Lancet,2020

2. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention;Wu;JAMA,2020